EVALUATION OF SHIGELLA VACCINE SAFETY AND EFFICACY IN AN INTRANASALLY CHALLENGED MOUSE MODEL

被引：70

作者：

MALLETT, CP ^{[1
]}

VANDEVERG, L ^{[1
]}

COLLINS, HH ^{[1
]}

HALE, TL ^{[1
]}

机构：

[1] WALTER REED ARMY INST RES, DEPT ENTER INFECT, WASHINGTON, DC 20307 USA

来源：

VACCINE | 1993年 / 11卷 / 02期

关键词：

SHIGELLA-FLEXNERI VACCINATION; INTRANASAL CHALLENGE; MOUSE MODEL;

D O I：

10.1016/0264-410X(93)90016-Q

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Five Shigella vaccine candidates (EcSf2a-1, EcSf2a-2, Sfl124, T32-Istrati and SMD) were tested for safety and efficacy in Balb/cJ mice using an intranasal challenge model. Experiments in this model suggest that (i) the relative attenuation of vaccines can be determined in mice by intranasal inoculation, (ii) all vaccines tested elicited antibacterial mucosal immunity protecting against pulmonary infection with Shigella flexneri 2a, (iii) protection was associated with serum IgA and/or IgG antibody recognizing the 2a somatic antigen.

引用

页码：190 / 196

页数：7

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