DEVELOPMENT OF GLUTATHIONE-S-TRANSFERASE PLACENTAL FORM (GST-P) STAINED FOCI DURING HAMSTER BUCCAL POUCH MUCOSA CARCINOGENESIS

被引：15

作者：

ZHANG, L

MOCK, D

CAMERON, R

机构：

[1] UNIV TORONTO,FAC DENT,TORONTO M5S 1A1,ONTARIO,CANADA

[2] UNIV TORONTO,DEPT PATHOL,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

CANCER LETTERS | 1992年 / 64卷 / 03期

关键词：

HAMSTERS; GOLDEN SYRIAN; DIMETHYLBENZ[A]ANTHRACENE; GLUTATHIONE TRANSFERASE;

D O I：

10.1016/0304-3835(92)90049-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of the placental form of glutathione S-transferase (GST-P) using anti-rat liver GST-P antibody was investigated in hamster buccal pouch mucosa (HBPM) treated with 0.5% dimethylbenz[a]anthracene (DMBA) biweekly for 12 weeks. This preliminary study showed that the anti-rat liver GST-P antibody is applicable to the HBPM model and that DMBA treatment induced GST-P positive foci. These foci are randomly distributed and frequently involved the hyperplastic and dysplastic segments of the epithelium, as well as squamous cell carcinoma. Further study is needed to explore the kinetics of these GST-P positive foci.

引用

收藏

页码：241 / 247

页数：7

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