MONOCYTE ADHERENCE TO ENDOTHELIAL-CELLS IN PATIENTS WITH ATHEROSCLEROSIS - RELATIONSHIPS WITH RISK-FACTORS

被引：28

作者：

DUPLAA, C ^{[1
]}

COUFFINHAL, T ^{[1
]}

LABAT, L ^{[1
]}

FAWAZ, J ^{[1
]}

MOREAU, C ^{[1
]}

BIETZ, I ^{[1
]}

BONNET, J ^{[1
]}

机构：

[1] INSERM,UNITE CARDIOL 8,AVE HAUT LEVEQUE,F-33600 PESSAC,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 23卷 / 08期

关键词：

ADHESION; ENDOTHELIUM; FIBRINOGEN; MONOCYTE; OXIDIZED LDL; PEROXIDATION; TOBACCO;

D O I：

10.1111/j.1365-2362.1993.tb00793.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Monocyte adhesion to endothelium appearing determinant in atherosclerosis, the possibility that circulating monocytes have an increase of their adherence on endothelial cells were investigated in patients with atherosclerosis. The adherence of circulating monocytes on endothelial cell monolayers was determined in 26 patients with atherosclerosis (age 59+/-4), and 25 healthy individuals (age 55+/-4). No difference of monocyte adherence was observed between the two groups (18.8+/-13.8% vs 19.2+/-13.4%), or following atherosclerosis severity. However monocyte adherence appeared positively correlated to smoking habits (r=0.34, P<0.02) and fibrinogen level (r=0.31, P<0.03), and negatively to the degree of plasmatic LDL oxidation (r=-0.28, P<0.05). These results suggest that the adherence of monocytes to endothelial cells is not increased in atherosclerosis, but enhanced by risk factors. A weak plasmatic LDL oxydation could inhibit monocyte adhesion.

引用

页码：474 / 479

页数：6

共 60 条

[1]

ABBOUD RT, 1986, J LAB CLIN MED, V108, P294

[2]

ALDERSON LM, 1986, AM J PATHOL, V123, P334

[3]

ALLAIN CC, 1974, CLIN CHEM, V20, P470

[4] BINDING OF FIBRINOGEN TO HUMAN-MONOCYTES [J].

ALTIERI, DC ;

MANNUCCI, PM ;

CAPITANIO, AM .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (04) :968-976

[5] PRESENCE OF A MODIFIED LOW-DENSITY LIPOPROTEIN IN HUMANS [J].

AVOGARO, P ;

BON, GB ;

CAZZOLATO, G .

ARTERIOSCLEROSIS, 1988, 8 (01) :79-87

[6] MINIMALLY MODIFIED LOW-DENSITY-LIPOPROTEIN STIMULATES MONOCYTE ENDOTHELIAL INTERACTIONS [J].

BERLINER, JA ;

TERRITO, MC ;

SEVANIAN, A ;

RAMIN, S ;

KIM, JA ;

BAMSHAD, B ;

ESTERSON, M ;

FOGELMAN, AM .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (04) :1260-1266

[7]

BERLINER S, 1987, TRHOMB HAEMOST, V104, P1403

[8] ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 - AN INDUCIBLE RECEPTOR FOR NEUTROPHILS RELATED TO COMPLEMENT REGULATORY PROTEINS AND LECTINS [J].

BEVILACQUA, MP ;

STENGELIN, S ;

GIMBRONE, MA ;

SEED, B .

SCIENCE, 1989, 243 (4895) :1160-1165

[9]

Burnstein M, 1970, J LIPID RES, V11, P583

[10]

CHANYEUNG M, 1983, AM REV RESPIR DIS, V127, P172

← 1 2 3 4 5 6 →