The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor

被引：159

作者：

Besmer, Peter ^{[1
,2
]}

机构：

[1] Sloan Kettering Inst, Program Mol Biol, 1275 York Ave, New York, NY 10021 USA

[2] Cornell Univ, Grad Sch Med Sci, New York, NY 10021 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1991年 / 3卷 / 06期

关键词：

D O I：

10.1016/0955-0674(91)90111-B

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The c-kit receptor and its recently identified ligand are allelic with the murine White Spotting and Steel loci, respectively. These observations brought to light the functions of the c-kit receptor system in melanogenesis, gametogenesis and hematopoeisis during embryogenesis and in postnatal life. The recent molecular analysis of several White Spotting and Steel alleles has provided insights into the mechanism of c-kit ligand-mediated processes, including cell proliferation, cell migration and cell survival. Furthermore, the availability of the kit ligand has allowed in vitro investigations of the pleiotropic functions of c-kit in development and cell differentiation to be carried out.

引用

页码：939 / 946

页数：8

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