TRANSCRIPTION AND DNA SUPERCOILING

被引：111

作者：

WANG, JC ^{[1
]}

LYNCH, AS ^{[1
]}

机构：

[1] HARVARD UNIV, CAMBRIDGE, MA 02138 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(05)80096-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transcription and supercoiling of the DNA template are interrelated. This review summarizes recent progress in the study of how template topology affects transcription, and how transcription affects template topology inside wild-type and DNA topoisomerase mutant cells. The interplay between DNA supercoiling and transcription raises interesting questions on the regulation of adjacent genes, the organization of intracellular DNA, and the coupling between transcription and other cellular processes involving DNA.

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页码：764 / 768

页数：5

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