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EXTENSION OF LIFE-SPAN BY OVEREXPRESSION OF SUPEROXIDE-DISMUTASE AND CATALASE IN DROSOPHILA-MELANOGASTER

被引：1205
作者：
ORR, WC
SOHAL, RS
机构：
[1] Department of Biological Sciences, Southern Methodist University, Dallas
来源：
SCIENCE | 1994年 / 263卷 / 5150期
关键词：
D O I：
10.1126/science.8108730
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging.
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页码：1128 / 1130
页数：3
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