PHOSPHOLIPASE A(2) GENE-EXPRESSION AND ACTIVITY IN HISTOLOGICALLY NORMAL ILEAL MUCOSA AND IN CROHNS ILEITIS

被引：38

作者：

LILJA, I

SMEDH, K

OLAISON, G

SJODAHL, R

TAGESSON, C

GUSTAFSONSVARD, C

机构：

[1] LINKOPING UNIV,FAC HLTH SCI,DEPT OCCUPAT & ENVIRONM MED,S-58185 LINKOPING,SWEDEN

[2] LINKOPING UNIV,FAC HLTH SCI,DEPT SURG,LINKOPING,SWEDEN

来源：

GUT | 1995年 / 37卷 / 03期

关键词：

DISTAL ILEUM; DISTAL SMALL INTESTINE; INFLAMMATION; MESSENGER RIBONUCLEIC ACID; POLYMERASE CHAIN REACTION;

D O I：

10.1136/gut.37.3.380

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Increased activity of phospholipase A(2) (PLA(?)2) in the heal mucosa may contribute to the inflammation in Crohn's disease. The results of this study showed that (a) three months after ileocolonic resection for Crohn's disease the neoterminal ileal mucosa showed endoscopically new inflammation and had higher PLA(2) activity than at the time of the operation (n = 8); no such findings were seen in controls (n = 7), (b) histologically normal ileal mucosa (n = 3) contained mRNA for three isoforms of PLA(2) (PLA(2)-I, PLA(2)-II, and cPLA(2)), but the amounts of PLA(2)-II mRNA clearly exceeded the amounts of mRNA for PLA(2)-I and cPLA(2), (c) ileal mucosa from Crohn's patients (n = 2) contained higher values of PLA(2)-II mRNA than ileal mucosa from two controls, (d) ileal mucosa from Crohn's patients (n = 4) showed increased PLA(2)-II mRNA three months after ileocolonic resection. In conclusion, these results show that the predominating PLA(2) mRNA in the human ileal mucosa is type II PLA(2), and that increased synthesis of PLA(2)-II might be responsible for the increased PLA(2) activity found in the heal mucosa accompanying recurrent heal inflammation in Crohn's disease.

引用

页码：380 / 385

页数：6

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