EFFECTS OF STRESS AND EBIRATIDE (HOE-427) ON FREE-CHOICE ETHANOL-CONSUMPTION - COMPARISON OF LEWIS AND SPRAGUE-DAWLEY RATS

被引：18

作者：

SPRAGUE, JE

MAICKEL, RP

机构：

[1] Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette

来源：

LIFE SCIENCES | 1994年 / 55卷 / 11期

关键词：

LEWIS RAT; SPRAGUE-DAWLEY RAT; STRESS; EBIRATIDE; ADRENOCORTICOTROPIC HORMONE; ETHANOL CONSUMPTION;

D O I：

10.1016/0024-3205(94)90043-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of immobilization stress, isolation stress and administration of Hoe-427 on free-choice consumption of ethanol by Lewis and Sprague-Dawley rats were studied. The animals were offered two-bottle choice consumption of 0.2% saccharin and 10% ethanol/0.2% saccharin, then exposed to 4 days of immobilization stress or isolation stress on an irregular, unpredictable schedule or 4 days of i.p. doses of Hoe-427 at 1800 hours. Both stresses resulted in significant decreases in ethanol consumption during the stress period. Hoe-427 produced a significant decrease in ethanol consumption, in a dose-dependent manner. Saccharin consumption was not significantly affected by any of the treatments. The ability to correlate the Lewis and Sprague-Dawley rat response further aids in supporting the role of the adrenocorticotropic peptide in the development of ethanol consumption.

引用

页码：873 / 878

页数：6

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