NOSOCOMIAL TRANSMISSION OF TUBERCULOSIS INFECTION IN PEDIATRICS WARDS

被引:25
作者
AZNAR, J [1 ]
SAFI, H [1 ]
ROMERO, J [1 ]
ALEJO, A [1 ]
GRACIA, A [1 ]
PALOMARES, JC [1 ]
机构
[1] UNIV HOSP VIRGEN,DEPT PEDIAT,PEDIAT INFECT DIS SECT,SEVILLE,SPAIN
关键词
TUBERCULOSIS; NOSOCOMIAL TRANSMISSION; MOLECULAR EPIDEMIOLOGY;
D O I
10.1097/00006454-199501000-00009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Analysis of restriction fragment length polymorphisms is a well established method of ''DNA fingerprinting'' that has been used to trace the transmission of particular strains of Mycobacterium tuberculosis during investigations of outbreaks. This report describe the use of restriction fragment length polymorphisms and arbitrarily primed polymerase chain reaction analysis to investigate two outbreaks of tuberculosis that affected six children who attended two pediatric wards in our hospital. In both outbreaks a history of household exposure to an adult with M. tuberculosis was obtained and suspected tuberculous contacts were identified. We have demonstrated unequivocally the strain relationship among the isolates in all the cases by restriction fragment length polymorphisms and arbitrarily primed polymerase chain reaction analysis. These techniques are very useful for performing epidemiologic studies of tuberculosis in children where natural history of tuberculosis infection is different from that in adults in that it is almost always primary infection rather than reactivation.
引用
收藏
页码:44 / 48
页数:5
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