INFLUENCE OF LYNESTRENOL ON RATE OF METABOLISM OF PHENOBARBITAL PHENYTOIN AND HEXOBARBITAL IN MICE

被引：19

作者：

RUMKE, CL

NOORDHOEK, J

机构：

[1] Department of Pharmacology and Neurobiochemistry, Free University, Amsterdam

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1969年 / 6卷 / 02期

关键词：

Enzyme induction; Hexobarbital; Lynestrenol; Phenobarbital; Phenytoin Drug metabolism;

D O I：

10.1016/0014-2999(69)90213-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lynestrenol, given 48 hr beforehand, enhances the elimination of phenobarbital and phenytoin from mouse plasma and consequently diminishes their anticonvulsant effect. The hexobarbital sleeping time is shortened and the in vitro metabolism of hexobarbital is accelerated by the same pretreatment. The increase of the rate of phenobarbital and phenytoin elimination may be due to acceleration of their metabolism by lynestrenol. © 1969.

引用

页码：163 / +

页数：1

共 9 条

[1]

BRODIE BB, 1953, J PHARMACOL EXP THER, V109, P26

[2]

CONNEY AH, 1967, PHARMACOL REV, V19, P317

[3]

DEJONGH DK, 1957, ACTA PHYSIOL PHARM N, V6, P511

[4] EFFECTS OF NORETHYNODREL AND PROGESTERONE ON HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEMS [J].