PEPTIDOGLYCAN TRANSPEPTIDASE INHIBITION IN PSEUDOMONAS-AERUGINOSA AND ESCHERICHIA-COLI BY PENICILLINS AND CEPHALOSPORINS

被引:20
作者
MOORE, BA
JEVONS, S
BRAMMER, KW
机构
关键词
D O I
10.1128/AAC.15.4.513
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Peptidoglycan transpeptidase activity has been studied in cells of E.coli 146 and P. aeruginosa 56 made permeable to exogenous, nucleotide-sugar peptidoglycan precursors by ether treatment. Transpeptidase activity was inhibited, in both organisms, by a range of penicillins and cephalosporins, the Pseudomonas enzyme being more sensitive to inhibition in each case. Conversely, growth of E.coli 146 was more susceptible to these antibodies than growth of P.aeruginosa 56. Furthermore, similar transpeptidase inhibition values were obtained for the 4 penicillins examined against the Pseudomonas enzyme, although only two of these (carbenicillin kand pirbenicillin) inhibited the growth of this organism. It is therefore concluded that the high resistance of P. aeruginosa 56 to growth inhibition by most β-lactam antibodies cannot be due to an insensitive peptidoglycan transpeptidase.
引用
收藏
页码:513 / 517
页数:5
相关论文
共 21 条