INTRACEREBROVENTRICULAR BETHANECHOL FOR ALZHEIMERS-DISEASE - VARIABLE DOSE-RELATED RESPONSES

被引：21

作者：

READ, SL

FRAZEE, J

SHAPIRA, J

SMITH, C

CUMMINGS, JL

TOMIYASU, U

机构：

[1] UNIV CALIF LOS ANGELES, LOS ANGELES CTY HARBOR MED CTR, DEPT PSYCHIAT, TORRANCE, CA 90509 USA

[2] UNIV CALIF LOS ANGELES, LOS ANGELES CTY HARBOR MED CTR, DEPT NEUROL, TORRANCE, CA 90509 USA

[3] UNIV CALIF LOS ANGELES, SCH MED, DEPT NEUROSURG, LOS ANGELES, CA 90024 USA

[4] UNIV CALIF LOS ANGELES, SCH MED, DEPT NURSING, LOS ANGELES, CA 90024 USA

[5] UNIV CALIF LOS ANGELES, SCH MED, DEPT PSYCHOL, LOS ANGELES, CA 90024 USA

[6] UNIV CALIF LOS ANGELES, SCH MED, DEPT NEUROL & PSYCHIAT, LOS ANGELES, CA 90024 USA

[7] UNIV CALIF LOS ANGELES, SCH MED, DEPT PATHOL, LOS ANGELES, CA 90024 USA

[8] VET ADM MED CTR, LOS ANGELES, CA USA

来源：

ARCHIVES OF NEUROLOGY | 1990年 / 47卷 / 09期

关键词：

D O I：

10.1001/archneur.1990.00530090105020

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Five male patients participated in a pilot open-label study of dose-related aspects of response to intracerebroventricular bethanechol in Alzheimer's disease. No patient had remission of symptoms, but three patients improved symptomatically and on tests of memory. Improvement was evident over a restricted range of doses for each subject, and symptoms were worse at doses below and above the optimal range. There was little overlap in the range of doses producing improvement among these three. Two patients had no consistent improvement in memory, and agitation, depression, paranoia, and seizures developed during treatment. Qualitative differences and variability in dosages producing responses complicate the identification of true drug response in the treatment of Alzheimer's disease. © 1990, American Medical Association. All rights reserved.

引用

页码：1025 / 1030

页数：6

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