DROSOPHILA-MELANOGASTER DIPHENOL OXIDASE A2 - GENE STRUCTURE AND HOMOLOGY WITH THE MOUSE MAST-CELL TUM- TRANSPLANTATION ANTIGEN, P91A

被引：28

作者：

PENTZ, ES ^{[1
]}

WRIGHT, TRF ^{[1
]}

机构：

[1] UNIV VIRGINIA,INST MOLEC BIOL,CHARLOTTESVILLE,VA 22901

来源：

GENE | 1991年 / 103卷 / 02期

关键词：

RECOMBINANT DNA; SCLEROTIZATION; CATECHOLAMINE METABOLISM; MELANIZATION; PHENOL OXIDASES; TYROSINASES; IMMUNOGENIC MUTANTS;

D O I：

10.1016/0378-1119(91)90279-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Drosophila melanogaster diphenol oxidase (DOX) A2-encoding gene (Dox-A2) is involved in catecholamine metabolism, melanin formation and sclerotization of the cuticle. Insect phenol oxidases (POX) are well studied biochemically, but not genetically and molecularly. The Dox-A2 (2-53.9) gene is the first insect POX-encoding gene to be cloned and sequenced. It encodes a protein product unique among currently known POX. The deduced protein, however, exhibits extensive similarity (58-81%) to the mouse mast cell tum- antigen, P91A [Lurquin et al., Cell 58 (1989) 293-303] and may identify the normal mouse protein as a DOX.

引用

页码：239 / 242

页数：4

共 18 条

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