SIGNAL TRANSDUCTION THROUGH THE T-CELL ANTIGEN RECEPTOR

被引:45
作者
ABRAHAM, RT
KARNITZ, LM
SECRIST, JP
LEIBSON, PJ
机构
[1] Department of Immunology, Mayo Clinic, Rochester
关键词
D O I
10.1016/0968-0004(92)90015-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The mechanism by which ligand binding to the T-cell antigen receptor triggers the T-cell activation program has long been one of the most fascinating questions in lymphocyte biology. Here, we review recent insights into the transmembrane signaling functions of this multisubunit receptor complex.
引用
收藏
页码:434 / 438
页数:5
相关论文
共 29 条
  • [1] BANIYASH M, 1988, J BIOL CHEM, V263, P18225
  • [2] STRUCTURAL REQUIREMENTS FOR ENHANCEMENT OF T-CELL RESPONSIVENESS BY THE LYMPHOCYTE-SPECIFIC TYROSINE PROTEIN-KINASE P56LCK
    CARON, L
    ABRAHAM, N
    PAWSON, T
    VEILLETTE, A
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (06) : 2720 - 2729
  • [3] THE ZETA-CHAIN IS ASSOCIATED WITH A TYROSINE KINASE AND UPON T-CELL ANTIGEN RECEPTOR STIMULATION ASSOCIATES WITH ZAP-70, A 70-KDA TYROSINE PHOSPHOPROTEIN
    CHAN, AC
    IRVING, BA
    FRASER, JD
    WEISS, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) : 9166 - 9170
  • [4] REGULATION OF T-CELL RECEPTOR SIGNALING BY A SRC FAMILY PROTEIN-TYROSINE KINASE (P59FYN)
    COOKE, MP
    ABRAHAM, KM
    FORBUSH, KA
    PERLMUTTER, RM
    [J]. CELL, 1991, 65 (02) : 281 - 291
  • [5] DIFFERENTIAL REGULATION OF T-CELL ANTIGEN RESPONSIVENESS BY ISOFORMS OF THE SRC-RELATED TYROSINE PROTEIN-KINASE P59FYN
    DAVIDSON, D
    CHOW, LML
    FOURNEL, M
    VEILLETTE, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (06) : 1483 - 1492
  • [6] STIMULATION OF P21RAS UPON T-CELL ACTIVATION
    DOWNWARD, J
    GRAVES, JD
    WARNE, PH
    RAYTER, S
    CANTRELL, DA
    [J]. NATURE, 1990, 346 (6286) : 719 - 723
  • [7] TYROSYL PHOSPHORYLATION AND ACTIVATION OF MAP KINASES BY P56LCK
    ETTEHADIEH, E
    SANGHERA, JS
    PELECH, SL
    HESSBIENZ, D
    WATTS, J
    SHASTRI, N
    AEBERSOLD, R
    [J]. SCIENCE, 1992, 255 (5046) : 853 - 855
  • [8] T-CELL DEVELOPMENT AND TRANSMEMBRANE SIGNALING - CHANGING BIOLOGICAL RESPONSES THROUGH AN UNCHANGING RECEPTOR
    FINKEL, TH
    KUBO, RT
    CAMBIER, JC
    [J]. IMMUNOLOGY TODAY, 1991, 12 (02): : 79 - 85
  • [9] GRANJA C, 1991, J BIOL CHEM, V266, P16277
  • [10] HUTCHCROFT JE, 1991, J BIOL CHEM, V266, P14846