DEPLETION OF LANGERHANS CELLS IN CERVICAL HPV INFECTION IS ASSOCIATED WITH REPLICATION OF THE VIRUS

被引：16

作者：

LEHTINEN, M

RANTALA, I

TOIVONEN, A

LUOTO, H

AINE, R

LAUSLAHTI, K

YLAOUTINEN, A

ROMPPANEN, U

PAAVONEN, J

机构：

[1] UNIV TAMPERE,INST BIOMED SCI,TAMPERE,FINLAND

[2] TAMPERE UNIV,CENT HOSP,DEPT PATHOL,TAMPERE,FINLAND

[3] TAMPERE UNIV,CENT HOSP,DEPT OBSTET & GYNECOL,TAMPERE,FINLAND

[4] MUNICIPAL HLTH ADM,TAMPERE,FINLAND

[5] UNIV HELSINKI,CENT HOSP,SF-00100 HELSINKI 10,FINLAND

来源：

APMIS | 1993年 / 101卷 / 11期

关键词：

ELISA; HUMAN PAPILLOMAVIRUS; IN-SITU HYBRIDIZATION; LANGERHANS CELLS; TETRAPLOIDY;

D O I：

10.1111/j.1699-0463.1993.tb00188.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the quantity of Langerhans cells in 36 patients with cervical human papillomavirus (HPV) infection. Significantly fewer Langerhans cells (p < 0.05) were found in patients with compared to those without DNA tetraploidy. Similarly, patients positive for HPV 16/18 DNA by in situ hybridization or antipeptide IgA antibodies to HPV 18 tended to have fewer Langerhans cells than those negative for HPV 16/18 DNA or IgA antibodies. Our results suggest that depletion of Langerhans cells is associated with productive HPV 16/18 infection in the cervical epithelium.

引用

页码：833 / 837

页数：5

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