AN ACID-CLEAVABLE LINKER STABLE AT NEUTRAL PH THAT RELEASES DOXORUBICIN AT LYSOSOMAL PH

被引：2

作者：

DUBOWCHIK, GM

PADILLA, LM

FIRESTONE, RA

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492-7660

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80776-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A Kemp's triacid amide of doxorubicin (DOX), esterified at a second carboxyl, releases DOX at lysosomal pH at a reasonable rate but is extremely stable at neutral pH.

引用

页码：2843 / 2846

页数：4

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