ANTIDEPRESSANT-LIKE EFFECT OF LY228729 AS MEASURED IN THE RODENT FORCED SWIM PARADIGM

被引：13

作者：

BENVENGA, MJ

LEANDER, JD

机构：

[1] The Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 239卷 / 1-3期

关键词：

ANTIDEPRESSANTS; FORCED SWIM TEST; 5-HT(1A) RECEPTOR AGONISTS; LY228729;

D O I：

10.1016/0014-2999(93)91005-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The novel 5-HT1A receptor agonist, LY228729, was tested to see if it would produce antidepressant-like behavioral effects in the rodent forced swim model. The tricyclic antidepressant, imipramine, as well as the 5-HT1A receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and gepirone, produced dose-related decreases in immobility in the forced swim test following subchronic treatment in rats. LY228729, when given over a three injection course, as with the other compounds, significantly reduced immobility at doses of 1 and 3 mg/kg. Subsequent analysis of locomotor activity revealed no increases in behavior, so that general changes in activity could not account for the reduction in immobility time in the forced swim. These results suggest that LY228729 may have clinical antidepressant efficacy.

引用

页码：249 / 252

页数：4

共 18 条

[1] GEPIRONE, A SELECTIVE SEROTONIN (5HT(1A)) PARTIAL AGONIST IN THE TREATMENT OF MAJOR DEPRESSION [J].