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HUMAN HEMATOLYMPHOID CELLS IN SCID MICE

被引：29
作者：
KANESHIMA, H [1 ]
NAMIKAWA, R [1 ]
MCCUNE, JM [1 ]
机构：
[1] DNAX RES INST MOLEC & CELLULAR BIOL INC,PALO ALTO,CA 94304
来源：
CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 02期
关键词：
D O I：
10.1016/0952-7915(94)90109-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The severe combined immunodeficient C.B.-17 scid/scid (SCID) mouse has been widely used to study the normal processes of murine lymphoid differentiation. To create an in vivo model of the human hematolymphoid system, this mouse strain has been engrafted with human organ systems (the SCID-hu mouse) or with human peripheral blood mononuclear cells (the hu-PBL-SCID mouse). These mouse models have now been characterized and used to analyze human infectious diseases, hematopoiesis, malignancies and vaccines.
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页码：327 / 333
页数：7
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