Scientific Opinion on the risks for animal and public health related to the presence of Alternaria toxins in feed and food

被引：219

作者：

Alexander, Jan ^{[1
]}

Benford, Diane ^{[1
]}

Boobis, Alan ^{[1
]}

Ceccatelli, Sandra ^{[1
]}

Cottrill, Bruce ^{[1
]}

Cravedi, Jean-Pierre ^{[1
]}

Di Domenico, Alessandro ^{[1
]}

Doerge, Daniel ^{[1
]}

Dogliotti, Eugenia ^{[1
]}

Edler, Lutz ^{[1
]}

Farmer, Peter ^{[1
]}

Filipic, Metka ^{[1
]}

Fink-Gremmels, Johanna ^{[1
]}

Fuerst, Peter ^{[1
]}

Guerin, Thierry ^{[1
]}

Knutsen, Helle Katrine ^{[1
]}

Machala, Miroslav ^{[1
]}

Mutti, Antonio ^{[1
]}

Schlatter, Josef ^{[1
]}

Rose, Martin ^{[1
]}

van Leeuwen, Rolaf ^{[1
]}

机构：

[1] EFSA, Parma, Italy

来源：

EFSA JOURNAL | 2011年 / 9卷 / 10期

关键词：

Mycotoxins; Alternaria toxins; food; feed; analysis; occurrence; dietary exposure; animal exposure; risk assessment; toxicity;

D O I：

10.2903/j.efsa.2011.2407

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The European Commission asked the European Food Safety Authority to review the safety of Alternaria toxins in food and feed. In addition to causing plant diseases on many crops such as cereals, oilseeds, tomatoes, apples and olives, some of these toxins are genotoxic in vitro and/or fetotoxic in rats. This opinion deals with alternariol, alternariol monomethyl ether, tenuazonic acid, iso-tenuazonic acid, altertoxins, tentoxin, altenuene and AAL-toxins (Alternaria alternata f. sp. lycopersici toxins). Two Member States provided 11,730 occurrence results in food and also data published in the scientific literature were considered. Generally these toxins were found in grains and grain-based products, tomato and tomato products, sunflower seeds and sunflower oil, fruits and fruit products, and beer and wine. The feed occurrence data (1150 results) were collected from the literature only. The knowledge on toxic effects of Alternaria toxins on farm and companion animals and occurrence data in feed were insufficient to assess the health risk for different species. For chicken there are indications that alternariol represents a health risk but it cannot be excluded that tenuazonic acid could also be of concern. Considering: (1) there are few or no relevant toxicity data on Alternaria toxins, (2) the chemical structure of several of them is known, (3) dietary exposure data exist for some of them, the Panel on Contaminants in the food chain used the threshold of toxicological concern (TTC) approach to assess the relative level of concern for dietary exposure of humans to these mycotoxins. For the genotoxic Alternaria toxins, alternariol and alternariol monomethyl ether, the estimated chronic dietary exposure exceeded the relevant TTC value indicating a need for additional toxicity data. The dietary exposure estimates for non-genotoxic tentoxin and tenuazonic acid are lower than the relevant TTC value and are considered unlikely to be a human health concern. (C) European Food Safety Authority, 2011

引用

页数：97

共 211 条

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