CHROMOSOMAL ANALYSIS OF HUMAN OOCYTES FERTILIZED BY MICROINJECTION OF SPERMATOZOA INTO THE PERIVITELLINE SPACE

被引：36

作者：

KOLA, I

LACHAM, O

JANSEN, RPS

TURNER, M

TROUNSON, A

机构：

[1] Centre for Early Human Development, Monash University

[2] Sydney IVF, Sydney

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 05期

关键词：

Chromosomal abnormalities; IVF; Male factor infertility; Sperm microinjection;

D O I：

10.1093/oxfordjournals.humrep.a137147

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In-vitro fertilization by sperm microinjection techniques have been shown to be effective (the birth of one child has resulted), but concerns about the chromosomal normality of embryos derived from this process have been raised. The British Interim Licensing Authority has set, as a pre-condition to the clinical application of sperm microinjection, the chromosomal evaluation of pre-embryos derived by this technique. In this study, we demonstrate that four of 18 (22%) eggs fertilized by sperm microinjection into the perivitelline space are chromosomally abnormal as compared with nine of 30 (30%) fertilized by conventional IVF procedures. These results are not significantly different. In addition, we demonstrate that nine out of 20 couples who did not previously have fertilization in multiple cycles of IVF had between one and three oocytes fertilized by sperm microinjection. These findings demonstrate that sperm microinjection does not increase the incidence of chromosomally abnormal eggs and provide reassurance and support for the clinical implementation of a technique that appears to be effective for the treatment of certain forms of male infertility. © 1990 Oxford University Press.

引用

页码：575 / 577

页数：3

共 16 条

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