IMMUNOSTAINING OF HUMAN BRAIN CAPILLARIES BY ANTIBODIES TO VERY LATE ANTIGENS

被引：40

作者：

MCGEER, PL ^{[1
]}

ZHU, SG ^{[1
]}

DEDHAR, S ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PATHOL,CANC CONTROL AGCY BRITISH COLUMBIA,DEPT ADV THERAPEUT,VANCOUVER V6T 1W5,BC,CANADA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 26卷 / 03期

基金：

英国医学研究理事会;

关键词：

(Human); Antibody; Brain; Capillary; Immunostaining; Very late antigen;

D O I：

10.1016/0165-5728(90)90003-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Normal and neurologically diseased brain tissue was stained with antibodies directed against very late antigens (VLAs) 1, 2, 3, 5, 6, their common β1-subunit, and three extracellular proteins: collagen type IV, laminin and fibronectin. Strong staining of capillaries was obtained in both normal and pathological tissue with antibodies to collagen type IV and its putative receptor VLA-1; laminin and its putative receptor VLA-6; and the common VLA β1-subunit. Only residual plasma in vessels was stained with the antibody to fibronectin. Negative staining was obtained with antibodies to the fibronectin receptor VLA-5 and VLA-3. Trace staining was obtained with the antibody to VLA-2. © 1990.

引用

页码：213 / 218

页数：6

共 13 条

[1] Microscopic observations on the growth of blood capillaries in the living mammal [J].