TREATMENT OF MALIGNANT GLIOMAS WITH SURGERY, INTRAARTERIAL INFUSIONS OF 1-(2-HYDROXYETHYL)CHLOROETHYLNITROSOUREA, AND RADIATION-THERAPY - A PHASE-II STUDY

被引：16

作者：

FAUCHON, F

DAVILA, L

CHATELLIER, G

FOHANNO, D

PHILIPPON, J

REY, A

CHIRAS, J

POISSON, M

DELATTRE, JY

机构：

[1] GRP HOSP PITIE SALPETRIERE,DEPT NEUROL,F-75634 PARIS 13,FRANCE

[2] GRP HOSP PITIE SALPETRIERE,DEPT BIOSTAT,F-75634 PARIS 13,FRANCE

[3] GRP HOSP PITIE SALPETRIERE,DEPT NEUROSURG,F-75634 PARIS 13,FRANCE

[4] GRP HOSP PITIE SALPETRIERE,DEPT NEURORADIOL,F-75634 PARIS 13,FRANCE

[5] HOP BEAUJON,DEPT NEUROSURG,PARIS,FRANCE

[6] GRP HOSP PITIE SALPETRIERE,DEPT RADIAT THERAPY,F-75634 PARIS 13,FRANCE

来源：

NEUROSURGERY | 1990年 / 27卷 / 02期

关键词：

1-(2-Hydroxyethyl)chloroethylnitrosourea (HECNU); Intra-arterial chemotherapy; Malignant gliomas;

D O I：

10.1227/00006123-199008000-00010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Forty patients with malignant supratentorial gliomas were treated with surgery, intra-arterial infusions of 1-(2-hydroxyethyl)chloroethylnitrosourea, and radiation therapy. The median duration of survival was 12 months; it differed according to the histological subtype (over 30 months for patients with anaplastic astrocytomas or anaplastic oligodendroglioma and 10.5 months for glioblastoma; P = 0.0025). Serious complications of monocular blindness and leukoencephalopathy were observed in four patients (10%).

引用

页码：231 / 234

页数：4

共 25 条

[1] PRE-IRRADIATION INTERNAL CAROTID-ARTERY BCNU IN TREATMENT OF GLIOBLASTOMA-MULTIFORME [J].