GENETIC CONSERVATION OF CYCLOOXYGENASE

被引:12
作者
BENNETT, PR
MOORE, GE
机构
[1] Action Research Laboratory for the Molecular Biology of Fetal Development, Royal Post Graduate Medical School, Institute of Obstetrics and Gynaecology, London, W6 OXG England, Goldhawk Road
来源
PROSTAGLANDINS | 1991年 / 41卷 / 02期
关键词
D O I
10.1016/0090-6980(91)90026-C
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Homology between sheep and mouse cyclo-oxygenase cDNA and a range of other species was investigated using "zoo blots". Both the sheep and mouse cDNAs showed a high degree of homology to other species. Human cyclo-oxygenase appears to have greater homology to sheep and other ruminants than to mouse. Both sheep and mouse cDNAs detected identically sized transcripts in human placental total RNA.
引用
收藏
页码:135 / 142
页数:8
相关论文
共 8 条
[1]   CORTICOSTEROIDS SUPPRESS CYCLOOXYGENASE MESSENGER-RNA LEVELS AND PROSTANOID SYNTHESIS IN CULTURED VASCULAR CELLS [J].
BAILEY, JM ;
MAKHEJA, AN ;
PASH, J ;
VERMA, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (03) :1159-1163
[2]  
DEWITT D, J BIOL CHEM, V265, P5192
[4]  
HAMBERG M, 1970, J BIOL CHEM, V254, P5107
[5]   ISOLATION OF THE CDNA FOR HUMAN PROSTAGLANDIN-H SYNTHASE [J].
HLA, T ;
FARRELL, M ;
KUMAR, A ;
BAILEY, JM .
PROSTAGLANDINS, 1986, 32 (06) :829-845
[6]  
MERLIE JP, 1988, J BIOL CHEM, V263, P3550
[7]   PRIMARY STRUCTURE OF SHEEP PROSTAGLANDIN ENDOPEROXIDE SYNTHASE DEDUCED FROM CDNA SEQUENCE [J].
YOKOYAMA, C ;
TAKAI, T ;
TANABE, T .
FEBS LETTERS, 1988, 231 (02) :347-351
[8]   CLONING OF HUMAN-GENE ENCODING PROSTAGLANDIN ENDOPEROXIDE SYNTHASE AND PRIMARY STRUCTURE OF THE ENZYME [J].
YOKOYAMA, C ;
TANABE, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (02) :888-894