THE STRUCTURE-ACTIVITY RELATIONSHIP OF SKIN CARCINOGENICITY OF AROMATIC-HYDROCARBONS AND HETEROCYCLES

被引：50

作者：

ZHANG, LT ^{[1
]}

SANNES, K ^{[1
]}

SHUSTERMAN, AJ ^{[1
]}

HANSCH, C ^{[1
]}

机构：

[1] REED COLL,DEPT CHEM,PORTLAND,OR 97202

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1992年 / 81卷 / 1-2期

关键词：

STRUCTURE-ACTIVITY RELATIONSHIP; CARCINOGENICITY; POLYCYCLIC AROMATIC COMPOUNDS; SKIN CANCER;

D O I：

10.1016/0009-2797(92)90032-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From a study of 239 aromatic and heteroaromatic compounds causing skin cancer in mice, a quantitative structure-activity relationship has been derived. Carcinogenicity depends heavily on the relative hydrophobicity of the chemicals as defined by octanol/water partition coefficients (log P). It is also correlated with the energy of the highest occupied molecular orbital and the presence of substituents on the L and K regions of the carcinogen. The results are discussed in terms of the bay region concept for carcinogenic activity.

引用

页码：149 / 180

页数：32

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