CARBIDOPA ELEVATES HYPOTHALAMIC DOPA AND SERUM PROLACTIN IN RATS

被引：7

作者：

WATKINS, CJ

WIGGINS, JF

WURTMAN, RJ

机构：

[1] Laboratory of Neuroendocrine Regulation Department of Nutrition, Food Science Massachusetts Institute of Technology Cambridge

来源：

LIFE SCIENCES | 1979年 / 24卷 / 18期

关键词：

D O I：

10.1016/0024-3205(79)90252-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The administration of carbidopa (MK-486, α-methyl-L-dopa hydrazine; 100-200 mg/kg, intraperitoneally) causes several-fold increases in hypothalamic dopa and serum prolactin levels in male rats within 2 hours; these changes are not reversed by the administration of pyridoxine. These observations suggest that high doses of carbidopa can affect catecholamine synthesis within the hypothalamus. © 1979.

引用

页码：1675 / 1682

页数：8

共 27 条

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