24,25-DIHYDROXY-CHOLECALCIFEROL, A VITAMIN-D STEROL WITH QUALITATIVELY UNIQUE EFFECTS IN UREMIC MAN

被引：38

作者：

LLACH, F

BRICKMAN, AS

SINGER, FR

COBURN, JW

机构：

[1] VET ADM HOSP, MED SERV, SEPULVEDA, CA 91343 USA

[2] VET ADM WADSWORTH HOSP CTR, MED SERV, LOS ANGELES, CA 90073 USA

[3] VET ADM WADSWORTH HOSP CTR, RES SERV, LOS ANGELES, CA 90073 USA

[4] UNIV CALIF LOS ANGELES, SCH MED, DEPT MED, LOS ANGELES, CA 90024 USA

[5] UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USA

来源：

METABOLIC BONE DISEASE & RELATED RESEARCH | 1979年 / 2卷 / 01期

关键词：

24,25-dihydroxy-vitamin D[!sub]3[!/sub; Hemodialysis; Hypocalcemia; Parathyroid hormone; Uremia; Vitamin D;

D O I：

10.1016/0221-8747(79)90013-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The short-term effects of 24,25-dihydroxy-vitamin D3 (24,25(OH)2D3), 2.0 μg/day, 4.0 mg/day and 20 μg/day on serum calcium (Ca), phosphorus (Pi), alkaline phosphatase and intestinal absorption were evaluated in patients with advanced renal failure. The data show a small but significant fall in serum Ca and a rise in alkaline phosphatase. Both had returned to pretreatment levels two weeks after treatment was discontinued. Intestinal absorption of 47Ca was affected by 24,25(OH)2D3, only at the 20 μg/day dose. Serum iPTH either rose or was unchanged in 6 of 7 patients when this measurement was obtained. The effects on serum calcium and alkaline phosphatase differ considerably from those observed during treatment with 1,25(OH)2D3 or 25(OH)D3. This indicate that different vitamin D sterols can clearly exert different biological effects. Further information is needed to identify the mechanism of action of 24,25(OH)2D3 and clarify whether this effect is important under physiologic conditions. © 1979.

引用

页码：11 / 15

页数：5

共 27 条

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[2]

BOYLE IT, 1973, J BIOL CHEM, V248, P4174

[3] 1,25 DIHYDROXY-VITAMIN-D3 IN NORMAL MAN AND PATIENTS WITH RENAL-FAILURE [J].