INTRAREGIONAL DIFFERENCES IN THE ABSORPTION OF UNMODIFIED INSULIN FROM THE ABDOMINAL-WALL

被引：36

作者：

FRID, A

LINDE, B

机构：

[1] Departments of Clinical Physiology, Huddinge and Karolinska Hospitals

[2] Department of Medicine, University Hospital of Lund

来源：

DIABETIC MEDICINE | 1992年 / 9卷 / 03期

关键词：

FAT THICKNESS; INJECTION DEPTH; TYPE-1; DIABETES; RADIOLABELED INSULIN; ULTRASOUND; THIGH; ABDOMINAL WALL; INSULIN ABSORPTION;

D O I：

10.1111/j.1464-5491.1992.tb01768.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Absorption of subcutaneously injected unmodified human I-125-insulin (5 U; 100 U ml-1) was studied concurrently from three areas of the abdominal wall (120 mm above, 120 mm lateral to, and 40 mm below the umbilicus), and one area of the thigh (upper midline), in nine Type 1 diabetic patients of normal body weight, and from deep (2 mm above muscle fascia) and superficial (3 mm beneath skin surface) sites in abdominal wall and thigh in 11 Type 1 diabetic patients. The absorption rates were followed continuously for 3 h with the patient in the supine position. Whereas I-125-insulin disappeared considerably faster from the site above the umbilicus than from sites below or lateral to the umbilicus or from the thigh (residual radioactivities after 175 min: 36 +/- 4 vs 49 +/- 5, 54 +/- 2, and 62 +/- 4 (+/- SE) %, respectively; p < 0.05 or better), no significant differences were found between deep and superficial sites in either abdominal wall or thigh. The results suggest that insulin absorption rates from subcutaneous injection sites within the abdominal wall differ sufficiently for this to be of clinical importance.

引用

页码：236 / 239

页数：4

共 12 条

[1]

Binder C., Absorption of injected insulin, Acta Pharmacol Toxicol, 27, pp. 1-87, (1969)

[2]

Berger M., Cuppers HJ, Hegner H., Jorgens V., Berchtold P., Absorption kinetics and biological effects of subcutane‐ously injected insulin preparations, Diabetes Care, 5, pp. 77-91, (1982)

[3]

Frid A., Gunnarsson R., Guntner P., Linde B., Effects of accidental intramuscular injection on insulin absorption in insulin dependent diabetes, Diabetes Care, 11, pp. 41-45, (1988)

[4]

Koivisto VA, Felig P., Alterations in insulin absorption and in blood glucose control associated with varying insulin injection sites in diabetic patients, Ann Intern Med, 92, pp. 59-61, (1980)

[5]

Hildebrandt P., Sestoft L., Nielsen SL., The absorption of subcutaneously injected short‐acting soluble insulin: influence of injection technique and concentration, Diabetes Care, 6, pp. 459-462, (1983)

[6]

Heine RJ, Sikkenk AC, Bilo HJG, v d Meer J., v d Veen EA., Comparison of two commonly used insulin injection techniques, Diabetic Med, 2, pp. 175-176, (1985)

[7]

de Meijer PH, Lutterman JA, Van Lier HJ, van't Laar A., The variability of the absorption of subcutaneously injected insulin: effect of injection technique and relation with brittleness, Diabetic Med, 7, pp. 499-505, (1990)

[8]

Jorgensen KH, Larsen UD., Homogeneous mono‐125I‐insulins: Preparation and characterization of mono‐125I‐(Tyr A14)‐ and mono‐125I‐(Tyr A19)‐insulin, Diabetologia, 19, pp. 546-554, (1980)

[9]

Taylor R., Home PD, Alberti KGMM., Plasma free insulin profiles after administration of insulin by jet and conventional syringe injection, Diabetes Care, 4, pp. 377-379, (1981)

[10]

Edsberg B., Herly D., Hildebrandt P., Kuhl C., Insulin bolus given by a sprinkler needle: effect on absorption and glycaemic response to a meal, Br Med J, 294, pp. 1373-1376, (1987)

← 1 2 →