POSSIBLE INVOLVEMENT OF MYELOPEROXIDASE IN LIPID-PEROXIDATION

被引：89

作者：

STELMASZYNSKA, T ^{[1
]}

KUKOVETZ, E ^{[1
]}

EGGER, G ^{[1
]}

SCHAUR, RJ ^{[1
]}

机构：

[1] GRAZ UNIV,INST FUNCT PATHOL,A-8010 GRAZ,AUSTRIA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 01期

关键词：

D O I：

10.1016/0020-711X(92)90237-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Exposure of liposomes to the MPO-H2O2-Cl- system results in oxidation of lipids. Malondialdehyde and 4-hydroxynonenal are formed. 2. Oxidation of liposomes by stimulated rat neutrophils, assessed by malondialdehyde formation, is inhibited by KCN. This indicates involvement of MPO in the process. 3. The MPO-H2O2 system oxidizes mildly LDL but in the presence of chloride a propagation phase, with a rapid increase of conjugated diene formation, was observed.

引用

页码：121 / 128

页数：8

共 32 条

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