INDUCTION OF APOPTOSIS BY THE LOW-AFFINITY NGF RECEPTOR

被引:754
作者
RABIZADEH, S
OH, J
ZHONG, LT
YANG, J
BITLER, CM
BUTCHER, LL
BREDESEN, DE
机构
[1] UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024
[2] STANFORD RES INST,MENLO PK,CA 94025
[3] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024
[4] UNIV CALIF LOS ANGELES,DEPT PSYCHOL,LOS ANGELES,CA 90024
关键词
D O I
10.1126/science.8332899
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to Trk A, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75NGFR, remains uncertain. Expression of p75NGFR induced neural cell death constitutively when p75NGFR was unbound; binding by NGF or monoclonal antibody, however, inhibited cell death induced by p75NGFR. Thus, expression of p75NGFR may explain the dependence of some neural cells on NGF for survival. These findings also suggest that p75NGFR has some functional similarities to other members of a superfamily of receptors that include tumor necrosis factor receptors, Fas (Apo-1), and CD40.
引用
收藏
页码:345 / 348
页数:4
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