THE ROLE OF T(H)1 AND T(H)2 CELLS IN A RODENT MALARIA INFECTION

被引：343

作者：

TAYLORROBINSON, AW

PHILLIPS, RS

SEVERN, A

MONCADA, S

LIEW, FY

机构：

[1] UNIV GLASGOW,DEPT IMMUNOL,GLASGOW G11 6NT,SCOTLAND

[2] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

SCIENCE | 1993年 / 260卷 / 5116期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.8100366

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both T(H)1 and T(H)2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. T(H)1 cells protect by a nitric oxide-dependent mechanism, whereas T(H)2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.

引用

页码：1931 / 1934

页数：4

共 22 条

[1] THERAPY WITH MONOCLONAL-ANTIBODIES BY ELIMINATION OF T-CELL SUBSETS INVIVO
COBBOLD, SP
JAYASURIYA, A
NASH, A
PROSPERO, TD
WALDMANN, H
[J]. NATURE, 1984, 312 (5994) : 548 - 551
[2] NITRIC-OXIDE AS A SIGNAL IN BLOOD-VESSELS
KNOWLES, RG
MONCADA, S
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (10) : 399 - 402
[3] THE ROLE OF CD4+ T-CELLS IN THE IMMUNE-RESPONSE TO PLASMODIUM-CHABAUDI
LANGHORNE, J
[J]. PARASITOLOGY TODAY, 1989, 5 (11): : 362 - 364
[4] LEIST TP, 1984, J IMMUNOL, V138, P548
[5] A POSSIBLE NOVEL PATHWAY OF REGULATION BY MURINE T-HELPER TYPE-2 (TH2) CELLS OF A TH1 CELL-ACTIVITY VIA THE MODULATION OF THE INDUCTION OF NITRIC-OXIDE SYNTHASE ON MACROPHAGES
LIEW, FY
LI, Y
SEVERN, A
MILLOTT, S
SCHMIDT, J
SALTER, M
MONCADA, S
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (10) : 2489 - 2494
[6] MACROPHAGE OXIDATION OF L-ARGININE TO NITRITE AND NITRATE - NITRIC-OXIDE IS AN INTERMEDIATE
MARLETTA, MA
YOON, PS
IYENGAR, R
LEAF, CD
WISHNOK, JS
[J]. BIOCHEMISTRY, 1988, 27 (24) : 8706 - 8711
[7] PLASMODIUM-CHABAUDI - ANTIGENIC VARIATION DURING RECRUDESCENT PARASITEMIAS IN MICE
MCLEAN, SA
PEARSON, CD
PHILLIPS, RS
[J]. EXPERIMENTAL PARASITOLOGY, 1982, 54 (03) : 296 - 302
[8] PLASMODIUM-CHABAUDI - RELATIONSHIP BETWEEN THE OCCURRENCE OF RECRUDESCENT PARASITEMIAS IN MICE AND THE EFFECTIVE LEVELS OF ACQUIRED-IMMUNITY
MCLEAN, SA
PEARSON, CD
PHILLIPS, RS
[J]. EXPERIMENTAL PARASITOLOGY, 1982, 54 (02) : 213 - 221
[9] MELLOUK S, 1991, J IMMUNOL, V146, P3971
[10] STUDIES ON HETEROLOGOUS ANTI-LYMPHOCYTE SERUM IN MICE .3. IMMUNOLOGIC TOLERANCE AND CHIMERISM PRODUCED ACROSS H-2 LOCUS WITH ADULT THYMECTOMY AND ANTI-LYMPHOCYTE SERUM
MONACO, AP
WOOD, ML
RUSSELL, PS
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1966, 129 (A1): : 190 - +

← 1 2 3 →