ON THE ANTIGENIC DIVERSITY THRESHOLD-MODEL FOR AIDS

被引：9

作者：

STILIANAKIS, NI

SCHENZLE, D

DIETZ, K

机构：

[1] Department of Medical Biometry, University of Tübingen, Tübingen

来源：

MATHEMATICAL BIOSCIENCES | 1994年 / 121卷 / 02期

关键词：

D O I：

10.1016/0025-5564(94)90072-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this paper stochastic simulations of a model for AIDS pathogenesis developed by Nowak and coworkers are presented. The results reveal a strong dependency on initial conditions, and the model predicts a nonmonotonic hazard rate for the transition to AIDS. Doubts are raised concerning the significance of the ''antigenic diversity threshold,'' since it only partially characterizes the model dynamics.

引用

页码：235 / 247

页数：13

共 17 条

[1]

AMEISEN JC, 1991, IMMUNOL TODAY, V12, P102

[2]

ASCHER MS, 1990, J ACQ IMMUN DEF SYND, V3, P177

[3] THE HUMAN IMMUNODEFICIENCY VIRUS - INFECTIVITY AND MECHANISMS OF PATHOGENESIS [J].