GROWTH HORMONE-RELEASING PEPTIDE AND ITS ANALOGS - NOVEL STIMULI TO GROWTH-HORMONE RELEASE

被引:104
作者
KORBONITS, M
GROSSMAN, AB
机构
关键词
D O I
10.1016/1043-2760(94)00204-H
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
GHRPs are oligopeptides with GH-releasing effects in humans when given by either parenteral or oral routes; in addition, nonpeptide pharmacologic analogues have recently been synthesized. Although the exact mechanism of action of these agents has not been fully established, there is probably a dual sire of action on both the pituitary and the hypothalamus, possibly involving regulatory factors in addition to GHRH and somatostatin. GHRPs and their analogues may have a potential role in the treatment of short stature in children or in other situations of GH deficiency such as adult GH deficiency, obesity, catabolic states, and even normal old age.
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页码:43 / 49
页数:7
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