Oligonucleotide duplex stability controlled by the 7-substituents of 7-deazaguanine bases

被引：28

作者：

Seela, F

Ramzaeva, N

Chen, YM

机构：

[1] Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, D-49076 Osnabrück

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 24期

关键词：

D O I：

10.1016/0960-894X(95)00535-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oligonucleotides containing 7-substituted 7-deazaguanine residues (7-methyl, 7-iodol have been synthesized. The self-complementary octamer d(I(7)c(7)G-C)(4) containing 7-iodo-7-deaza-2'-deoxyguanosine forms a stabilized duplex compared to the parent oligomer d(G-C)(4) (Delta T-m = +10 degrees C). Also the complex between the oligodeoxynucleotide d(I(7)c(7)G(5)-G) and poly(C) is stabilized (Delta T-m = +10 degrees) over that of d(c(7)G(5)-G) with poly(C).

引用

页码：3049 / 3052

页数：4

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