THE EXPRESSION OF THE IMPRINTED H19 AND IGF-2 GENES IN HUMAN BLADDER-CARCINOMA

被引：81

作者：

ELKIN, M

SHEVELEV, A

SCHULZE, E

TYKOCINSKY, M

COOPER, M

ARIEL, I

PODE, D

KOPF, E

DEGROOT, N

HOCHBERG, A

机构：

[1] HEBREW UNIV JERUSALEM,ALEXANDER SILBERMAN INST LIFE SCI,DEPT BIOL CHEM,IL-91904 JERUSALEM,ISRAEL

[2] CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106

[3] CASE WESTERN RESERVE UNIV,DEPT MED,CLEVELAND,OH 44106

[4] HADASSAH UNIV HOSP,DEPT PATHOL,IL-91120 JERUSALEM,ISRAEL

[5] HADASSAH UNIV HOSP,DEPT UROL,IL-91120 JERUSALEM,ISRAEL

[6] WEIZMANN INST SCI,DEPT BIOCHEM,IL-76100 REHOVOT,ISRAEL

来源：

FEBS LETTERS | 1995年 / 374卷 / 01期

关键词：

GENOMIC IMPRINTING; BLADDER CARCINOMA; H19; IGF-2; MONO-ALLELIC EXPRESSION; BI-ALLELIC EXPRESSION;

D O I：

10.1016/0014-5793(95)01074-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults, However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA, Tumors induced by injection of bladder carcinoma cell Lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF-2 was observed in samples of human bladder carcinoma.

引用

页码：57 / 61

页数：5

共 28 条

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