SYNTHESIS OF CARBOHYDRATES VIA TANDEM USE OF THE OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION AND ENZYME-CATALYZED ALDOL ADDITION-REACTIONS

被引:65
作者
HENDERSON, I [1 ]
SHARPLESS, KB [1 ]
WONG, CH [1 ]
机构
[1] Scripps Res Inst, DEPT CHEM, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
关键词
D O I
10.1021/ja00081a016
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new strategy is described for the asymmetric synthesis of carbohydrate derivatives via the tandem use of the osmium-catalyzed asymmetric dihydroxylation (AD) and aldolase-catalyzed aldol addition reactions. Both D- and L-forms of fructose, 6-deoxy-galacto-2-heptulose, and 6-phenyl-galacto-2-hexulose were synthesized to illustrate this methodology.
引用
收藏
页码:558 / 561
页数:4
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