FUNCTIONAL EVIDENCE FOR A 5-HT2B RECEPTOR MEDIATING CONTRACTION OF LONGITUDINAL MUSCLE IN HUMAN SMALL-INTESTINE

被引：36

作者：

BORMAN, RA

BURLEIGH, DE

机构：

[1] Department of Pharmacology, Queen Mary and Westfield College, London, El 4NS, Mile End Road

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 114卷 / 08期

关键词：

HUMAN ILEUM; LONGITUDINAL MUSCLE; CONTRACTION; 5-HT2B RECEPTOR; SB; 200646A; YOHIMBINE;

D O I：

10.1111/j.1476-5381.1995.tb14935.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Application of 5-hydroxytryptamine induces contraction of longitudinal muscle strips from human terminal ileum. The response was resistant to antagonism by ketanserin, ondansetron or DAU6285, but was non-surmountably antagonized by methysergide. The selective 5-HT2B/2C receptor antagonist, SE 200646A evoked a concentration-dependent, parallel and dextral displacement of the concentration-response curve to 5-HT, yielding a pA(2) estimate of 7.17. Application of yohimbine, a 5-HT1 and 5-HT2B receptor antagonist, also induced a rightward shift of the response curve to 5-HT, yielding a pA(2) estimate of 8.10. In conclusion, it appears that a 5-HT2B receptor mediates the contractile response of the longitudinal muscle of human small intestine to 5-HT.

引用

页码：1525 / 1527

页数：3

共 10 条

[1] FURTHER CHARACTERIZATION OF 5-HYDROXYTRYPTAMINE RECEPTORS (PUTATIVE 5-HT2B) IN RAT STOMACH FUNDUS LONGITUDINAL MUSCLE [J].