HYPOCHOLESTEROLEMIC 5-SUBSTITUTED TETRAZOLES

被引：27

作者：

BUCHANAN, RL

SPRANCMA.V

PARTYKA, RA

机构：

[1] Research Division, Bristol Laboratories, Division of Bristol-Myers Company, Syracuse

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 06期

关键词：

D O I：

10.1021/jm00306a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of 5-aryloxyalkyl-, 5-arylthioalkyl-, and 5-anilinoalkyltetrazoles, along with a few other related 5-substituted tetrazoles, were synthesized by standard methods. A novel tetrazolylethylation reaction was used to synthesize 5-[β-(3-chlorophenoxy)ethyl]tetrazole (53) and 5-[β-(3-chlorophenylthio)ethyl]tetrazole (68). In general, the 5-arylthioalkyltetrazoles provided the best combination of high hypocholesterolemic activity and low toxicity. © 1969, American Chemical Society. All rights reserved.

引用

页码：1001 / &

共 29 条

[1] THE CHEMISTRY OF THE TETRAZOLES [J].