RUTHENIUM-CATALYZED HYDRATION OF NITRILES AND TRANSFORMATION OF DELTA-KETO NITRILES TO ENE-LACTAMS

被引：129

作者：

MURAHASHI, SI

SASAO, S

SAITO, E

NAOTA, T

机构：

[1] Department of Chemistry, Faculty of Engineering Science, Osaka University, Toyonaka, Osaka 560, Machikaneyama

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 09期

关键词：

D O I：

10.1021/jo00035a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydration of nitriles and transformation of delta-keto nitriles to ene-lactams can be performed efficiently by using RuH2(PPh3)4 catalyst under mild conditions. The effectiveness of the reaction is illustrated by the short-step synthesis of (-)-pumiliotoxin C.

引用

页码：2521 / 2523

页数：3

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