ON LINE CONTINUOUS MONITORING OF BLOOD LACTATE IN MEN BY A WEARABLE DEVICE BASED UPON AN ENZYMATIC AMPEROMETRIC LACTATE SENSOR

被引：39

作者：

MEYERHOFF, C ^{[1
]}

BISCHOF, F ^{[1
]}

MENNEL, FJ ^{[1
]}

STERNBERG, F ^{[1
]}

BICAN, J ^{[1
]}

PFEIFFER, EF ^{[1
]}

机构：

[1] UNIV ULM,INST DIABET TECHNOL,W-7900 ULM,GERMANY

来源：

BIOSENSORS & BIOELECTRONICS | 1993年 / 8卷 / 9-10期

关键词：

CONTINUOUS LACTATE SENSING; AMPEROMETRIC ENZYME ELECTRODE; LACTATE OXIDASE; PORTABLE LACTATE SENSOR; DOUBLE LUMEN CATHETER; STRENUOUS EXERCISE;

D O I：

10.1016/0956-5663(93)80025-K

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A wearable device for the continuous measurement of lactate in the blood was constructed by the combination of continuous blood sampling employing a double lumen catheter with an amperometric lactate sensor. In vitro, the lactate sensor turned out to have a linear concentration range between 0 and 15 mmol/l. The response time of the sensor itself amounted to 100 sec, whereas the lag time for blood sampling amounted to 2.2 min. In vivo, the lactate sensor was successfully used for the detection of changes of the blood lactate concentration following strenuous exercise in 7 healthy volunteers, in two cases up to 22 h. In conclusion, the technique of continuous blood sampling by the use of a double lumen catheter in combination with the amperometric lactate sensor is feasible and simplifies frequent blood lactate estimations.

引用

页码：409 / 414

页数：6

共 16 条

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