Inhibition of the induction of collagenase by interleukin-1 beta in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose) polymerase inhibitor 3-aminobenzamide

被引：23

作者：

Ehrlich, W ^{[1
]}

Huser, H ^{[1
]}

Kroger, H ^{[1
]}

机构：

[1] ROBERT KOCH INST,BIOCHEM ABT,D-13353 BERLIN,GERMANY

来源：

RHEUMATOLOGY INTERNATIONAL | 1995年 / 15卷 / 04期

关键词：

synovial fibroblasts; poly(ADP-ribosyl)ation; interleukin-1; beta; collagenase; 3-aminobenzamide;

D O I：

10.1007/BF00301776

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

3-Aminobenzamide is an inhibitor of poly(ADP-ribosyl)ation, In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at a concentration of 10 mM. We concluded that poly(ADP-ribosyl)ation plays a role in the induction of the expression of collagenase and that 3-aminobenzamide can inhibit this process.

引用

页码：171 / 172

页数：2

共 15 条

[1]

ALTHAUS FR, 1987, ADP RIBOSYLATION PRO, P115

[2] AUTO-REGULATION OF COLLAGENASE PRODUCTION BY A PROTEIN SYNTHESIZED AND SECRETED BY SYNOVIAL FIBROBLASTS - CELLULAR MECHANISM FOR CONTROL OF COLLAGEN DEGRADATION [J].