A 10-DEACETYLBACCATIN-III DERIVATIVE - 11,12-DIHYDRO-7-TRIETHYLSILYL-10-DEACETYLBACCATIN-III

The title compound (systematic name: 2a,3,4,4a,5,6,7,8,9,10,11,12,12a,1 2b-tetradecahydroxy-9,11-trihydroxy-4a,8,13,13-tetramethyl-4-triethylsiloxy-7,11-methano-1H-cyclodeca[3,4]benz[1,2b]oxete-12,W12b-diyl 12b-acetate 12-benzoate), C35H52O10Si was obtained from 10-deacetylbaccatin III by the reduction of the C11=C12 double bond of the 13-keto derivative. The saturation of the C11=C12 bond results in a large change in the orientation of the C13-OH hydroxy group. The distance between this group and the C4 acetyl group decreases leading to a strong hindrance of the hydroxy group, which explains the non-esterification at this position.