A NEW STRATEGY FOR THE SYNTHESIS OF POLYCHLORINATED BIPHENYL METABOLITES

被引：50

作者：

BAUER, U ^{[1
]}

AMARO, AR ^{[1
]}

ROBERTSON, LW ^{[1
]}

机构：

[1] UNIV KENTUCKY,GRAD CTR TOXICOL,LEXINGTON,KY 40506

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1995年 / 8卷 / 01期

关键词：

D O I：

10.1021/tx00043a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A general and high-yielding synthetic route is presented by which a variety of chlorinated dihydroxybiphenyl metabolites may be synthesized. These synthetic standards will permit the investigation of novel pathways of polychlorinated biphenyl activation. The biphenyldiols were synthesized via palladium-catalyzed cross-coupling of dimethoxyphenylboronic acids with aryl bromides in the presence of a base. The formed dimethoxybiphenyls were demethylated using boron tribromide to yield the chlorinated dihydroxybiphenyls. These compounds were characterized by IR, NMR, and GC/MS.

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页码：92 / 95

页数：4

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