CLOFAZIMINE - A REVIEW OF ITS MEDICAL USES AND MECHANISMS OF ACTION

被引：129

作者：

ARBISER, JL

MOSCHELLA, SL

机构：

[1] HARVARD UNIV,SCH MED,DEPT DERMATOL,BOSTON,MA

[2] LAHEY CLIN FDN,BURLINGTON,MA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1995年 / 32卷 / 02期

关键词：

D O I：

10.1016/0190-9622(95)90134-5

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action. The primary indication for clofazimine is multibacillary leprosy, but it is useful in several infectious and noninfectious diseases, such as atypical mycobacterial infections, rhinoscleroma, pyoderma gangrenosum, necrobiosis lipoidica, severe acne, pustular psoriasis, and discoid lupus erythematosus. Postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2. Clinical experience, possible mechanisms of action, and side effects of clofazimine are summarized.

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页码：241 / 247

页数：7

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