SYNTHESIS OF DIACYL-DL-(AND-L-) ALPHA-GLYCEROL PHOSPHATE

被引:45
作者
LAPIDOT, Y
BARZILAY, I
HAJDU, J
机构
[1] Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem
关键词
D O I
10.1016/0009-3084(69)90002-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis of α-DL (and L)-diacylglycerol phosphate is described. The method involves a direct acylation of glycerol-phosphate by fatty acid anhydride in the presence of the appropriate tetracthylammonium salt. It is shown that under the experimental conditions described in this paper, the phosphatidic acid was the sole reaction product and no cyclic phosphate could be detected. The procedure described is a general one and can be used for saturated as well as unsaturated fatty acids. © 1969.
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页码:125 / &
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共 28 条
[1]   Synthetic phosphatidic acids, II. Announcement. Representation of momo-acylated fat glycerin phosphoric acid. [J].
Arnold, H .
BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1938, 71 :1505-1510
[2]   Concerning chaulmoogra phosphatides. [J].
Arnold, H .
BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1940, 73 :90-94
[3]   Synthetic phosphatide acid, III. Announcement: Representation of caproic acid ester and lauric acid ester of beta-glycerine-phosphoric acids. [J].
Arnold, H .
BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1941, 74 :1736-1740
[4]   THE SYNTHESIS OF ACYL PHOSPHATES IN AQUEOUS SOLUTION [J].
AVISON, AWD .
JOURNAL OF THE CHEMICAL SOCIETY, 1955, :732-738
[5]  
BAER E, 1951, J BIOL CHEM, V189, P235
[6]  
BAER E, 1955, J BIOL CHEM, V212, P39
[7]  
BONSEN PPM, 1967, CHEM PHYS LIPIDS, V1, P100
[8]  
DEHAAS GH, 1963, BIOCHEM PROBL, P249
[9]  
FRAZER E, 1963, BIOCHEMICAL PROBL ED, P249
[10]   SEPARATION OF THE PHOSPHORIC ESTERS ON THE FILTER PAPER CHROMATOGRAM [J].
HANES, CS ;
ISHERWOOD, FA .
NATURE, 1949, 164 (4183) :1107-1112