RADIATION-THERAPY OF INVASIVE THYMOMA

被引：28

作者：

ARAKAWA, A ^{[1
]}

YASUNAGA, T ^{[1
]}

SAITOH, Y ^{[1
]}

UOZUMI, H ^{[1
]}

TAKADA, C ^{[1
]}

BABA, Y ^{[1
]}

YOSHIZUMI, K ^{[1
]}

TAKAHASHI, M ^{[1
]}

机构：

[1] KUMAMOTO CITY HOSP,DEPT RADIOL,KUMAMOTO,JAPAN

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 18卷 / 03期

关键词：

Myasthenia gravis; Radiation therapy; Thymoma; Total body irradiation;

D O I：

10.1016/0360-3016(90)90056-P

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Between 1978 and 1987, 30 cases of invasive thymomas were treated with radiotherapy after surgery. Surgical therapy consisted of total resection in 15 patients, subtotal resection in 1 patient, and biopsy in 14 patients. Myasthenia gravis (MG) was associated in nine patients (MG(+) group), but in 21 patients there was no evidence of myasthenia gravis (MG(-) group). Irradiation in the dose range of 30 to 58,7 Gy was delivered. The total average 5-year survival rate was 71.8%; it was 39.2% in MG(+) group and 78.3% in MG(-) group, though there was no significant statistical difference. Myasthenia gravis was well controlled by the tumorectomy and associated radiotherapy in 7 of the 9 patients. However, in 3 of 7 patients (42.9%) myasthenia gravis recurred at 2 years, 2 years and 7 months, and 5 years and 8 months after initial therapy. Total body irradiation of 2 Gy with 0.1 Gy fractions was administered for uncontrollable myasthenia gravis in one patient with marked improvement. Radiation therapy is an important therapeutic modality for unresectable malignant thymoma as well as for postoperative combined therapy. Total body irradiation may be an effective method to treat patients with otherwise resistant myasthenia gravis. © 1990.

引用

页码：529 / 534

页数：6

共 36 条

[1] MANAGEMENT OF MALIGNANT THYMOMA WITH RADIATION-THERAPY [J].