CHANGES OF CONTRACTILE AND ENDOTHELIUM-DEPENDENT RELAXANT RESPONSES FOLLOWING A 2-H HEMORRHAGIC HYPOTENSION IN CATS - REGIONAL DIFFERENCES

被引:9
作者
KOVACH, AGB
FARAGO, M
LOHINAI, Z
HORVATH, I
FEHER, E
OTTLAKAN, A
SZABO, C
机构
[1] SEMMELWEIS UNIV MED,SCH MED,INST PHYSIOL 2,H-1085 BUDAPEST 8,HUNGARY
[2] SEMMELWEIS UNIV MED,SCH MED,INST ANAT 1,H-1085 BUDAPEST 8,HUNGARY
关键词
ISOLATED ARTERIES; REGIONAL DIFFERENCES; HEMORRHAGIC SHOCK; ENDOTHELIUM-DERIVED RELAXING FACTOR; ENDOTHELIUM-DEPENDENT RELAXATION;
D O I
10.1097/00005344-199117003-00037
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of hemorrhagic shock on the reactivity of feline middle cerebral (MCA), mesenteric (MES), brachial (BRACH), renal (REN), and hepatic (HEP) arteries was studied in vitro. In sodium pentobarbital-treated cats, a steady level of hypotension (50 mm Hg) was reached by bleeding into a reservoir and maintained by further bleeding or autotransfusion during 2 h (shock). Rings of the arteries (from control animals and from animals after shock) were suspended for isometric tension recording in organ chambers. The experiments were performed in the presence of indomethacin and propranolol to inhibit cyclooxygenase and beta-adrenoceptors, respectively. Contractions induced by norepinephrine were enhanced in REN, whereas serotonin-evoked contractions were facilitated in MCA and REN, and depressed in BRACH significantly. The responses to prostaglandin F2-alpha remained unchanged in all vessels studied. Endothelium-dependent relaxations induced by acetylcholine were enhanced at lower (10(-8) M) and inhibited at higher (10(-6) M) concentrations in MCA and MES, and they were inhibited in REN, whereas the responses of BRACH and HEP were not affected significantly. Endothelium-dependent, ATP-induced dilations were inhibited in MCA. REN, and HEP and not affected in MES and BRACH. Adenosine-induced relaxations were inhibited only in MCA and MES. The present study suggests an impairment of the endothelial function in hemorrhagic shock, with marked regional heterogeneities. Possible mechanisms underlying the impairment of the endothelial function are discussed. The altered reactivity of the arteries might play a role in the development of various pathophysiological phenomena during hemorrhagic shock.
引用
收藏
页码:S198 / S206
页数:9
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