HETEROGENEITY OF RENIN ALLELES IN OUTBRED DAHL SALT-SENSITIVE (BROOKHAVEN) RATS

被引：14

作者：

ODOWD, BF

RAPP, JP

机构：

[1] MED COLL OHIO,DEPT MED,CS 10008,TOLEDO,OH 43699

[2] UNIV TORONTO,DEPT PHARMACOL,TORONTO M5S 1A1,ONTARIO,CANADA

[3] MED COLL OHIO,DEPT PATHOL,TOLEDO,OH 43699

[4] ADDICT RES FDN,TORONTO M5S 2S1,ONTARIO,CANADA

来源：

HYPERTENSION | 1991年 / 18卷 / 01期

关键词：

SALT-SENSITIVE HYPERTENSION; RENIN; DNA FINGERPRINTING GENETICS; DAHL RATS;

D O I：

10.1161/01.HYP.18.1.9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Selectively outbred Dahl salt-sensitive (DS) and salt-resistant (DR) rats were compared with the inbred Dahl salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats developed from the original Brookhaven stocks by J.P. Rapp. The animals were evaluated for genotype at the renin locus. The inbred strains are uniformly homozygous for their respective alleles, s in SS/Jr and r in SR/Jr. DR rats were also uniformly homozygous for the r renin allele. In DS rats, however, three renin alleles were segregating. In addition to the s and r alleles, a third allele, designated the z allele, was found. The gene frequencies in DS rats were s = 0.690, r = 0.284, and z = 0.026. Continued use of DS and DR rats in most experimental work is inappropriate because of genetic heterogeneity in the DS stock.

引用

页码：9 / 11

页数：3

共 21 条

[1] GENERAL METHOD FOR ISOLATION OF HIGH MOLECULAR-WEIGHT DNA FROM EUKARYOTES [J].