ETHANOL INHIBITION OF N-METHYL-D-ASPARTATE-ACTIVATED ION CURRENT IN RAT HIPPOCAMPAL-NEURONS IS NOT COMPETITIVE WITH GLYCINE

被引：82

作者：

PEOPLES, RW

WEIGHT, FF

机构：

[1] Section of Electrophysiology, Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville

来源：

BRAIN RESEARCH | 1992年 / 571卷 / 02期

关键词：

N-METHYL-D-ASPARTATE; ETHANOL; GLYCINE; HIPPOCAMPUS; RAT;

D O I：

10.1016/0006-8993(92)90674-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The interaction of ethanol with glycine at the N-methyl-D-aspartate (NMDA)-activated ion channel was investigated in voltage-clamped rat cultured hippocampal neurons. As shown previously, glycine increased, and ethanol inhibited, the NMDA-activated current in these cells. Concentration-response data for glycine (0.1-100-mu-M) indicate that the inhibition of NMDA-activated current by ethanol does not involve a competitive interaction with glycine. Thus, ethanol appears to inhibit NMDA-activated current at a locus different from the glycine modulatory site.

引用

页码：342 / 344

页数：3

共 14 条

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