DISTINCT FUNCTIONS OF SR PROTEINS IN ALTERNATIVE PREMESSENGER RNA SPLICING

被引：365

作者：

ZAHLER, AM

NEUGEBAUER, KM

LANE, WS

ROTH, MB

机构：

[1] FRED HUTCHINSON CANC RES CTR,DIV BASIC SCI,SEATTLE,WA 98104

[2] HARVARD UNIV,MICROCHEM FACIL,CAMBRIDGE,MA 02138

来源：

SCIENCE | 1993年 / 260卷 / 5105期

关键词：

D O I：

10.1126/science.8385799

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alternative splicing of precursor messenger RNAs (pre-mRNAs) is a common mechanism of regulating gene expression. SR proteins are a family of pre-mRNA splicing factors that are structurally related and evolutionarily conserved. Any member of the SR family can complement a splicing-deficient extract that lacks the entire family of SR proteins. Here it is demonstrated that particular SR proteins have distinct functions in alternative pre-mRNA splicing in vitro. In addition, SR proteins are differentially expressed in a variety of tissues. These results suggest a fundamental role for SR proteins in the regulation of alternative splicing.

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页码：219 / 222

页数：4

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