STUDIES WITH A XENOPUS BMP RECEPTOR SUGGEST THAT VENTRAL MESODERM-INDUCING SIGNALS OVERRIDE DORSAL SIGNALS IN-VIVO

被引：435

作者：

GRAFF, JM ^{[1
]}

THIES, RS ^{[1
]}

SONG, JJ ^{[1
]}

CELESTE, AJ ^{[1
]}

MELTON, DA ^{[1
]}

机构：

[1] GENET INST INC,CAMBRIDGE,MA 02140

来源：

CELL | 1994年 / 79卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0092-8674(94)90409-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the isolation of a Xenopus BMP receptor that is expressed maternally in the appropriate location to play a role in mesoderm induction. This receptor binds both BMP-2 and BMP-4 with high affinity. A truncated form of this BMP receptor specifically blocks BMP-4 signaling. Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm. Contrary to the popularly held view that ventral is the ground state for all mesoderm, our results suggest that formation of ventral mesoderm requires an active signal and that, in the absence of this ventral signal, dorsal mesoderm is formed.

引用

页码：169 / 179

页数：11

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